Glucocorticoids and Brown Adipose Tissue: Do glucocorticoids really inhibit thermogenesis?
نویسندگان
چکیده
منابع مشابه
Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo
INTRODUCTION Brown adipose tissue (BAT) is a thermogenic organ with substantial metabolic capacity and has important roles in the maintenance of body weight and metabolism. Regulation of BAT is primarily mediated through the β-adrenoceptor (β-AR) pathway. The in vivo endocrine regulation of this pathway in humans is unknown. The objective of our study was to assess the in vivo BAT temperature r...
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The growing understanding of adipose tissue as an important endocrine organ with multiple metabolic functions has directed the attention to the (patho)physiology of distinct fat depots. Brown adipose tissue (BAT), in contrast to bona fide white fat, can dissipate significant amounts of chemical energy through uncoupled respiration and heat production (thermogenesis). This process is mediated by...
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(Hales, J. R. S., eds.), pp. 169-173, Raven Press, New York Nedergaard, J., Alexson, S. & Cannon, B. (1980) Am. J . Physiol. 239, C208Z2 16 Nedergaard, J., Connolly, E., NBnberg, E. & Mohell, N. (1984) Biochem. Soc. Trans. 12, 393-396 Nedergaard, J., Connolly, E. & Cannon, B. (1986) in Brown Adipose Tissue (Trayhurn, P. & Nicholls, D. G., eds.), Edward Arnold, London, in the press Raasmaja, A.,...
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Heat production in brown adipose tissue contributes to cold defense, to stress-induced increases in body temperature, and to energy balance. Elucidating the functional organization of the central network controlling the sympathetic outflow to brown adipose tissue could provide a framework for understanding how dysregulation of thermogenesis contributes to hyperthermia and to obesity.
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Non-shivering thermogenesis in brown adipose tissue (BAT) plays an important role in thermoregulation. In addition, activations of BAT have important implications for energy homeostasis due to the metabolic consumption of energy reserves entailed in the production of heat in this tissue. In this conceptual overview we describe the role of orexins/hypocretins within the central nervous system in...
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ژورنال
عنوان ژورنال: Molecular Aspects of Medicine
سال: 2019
ISSN: 0098-2997
DOI: 10.1016/j.mam.2019.07.002